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- W2384239426 abstract "OBJECTIVE To establish a method for determining the concentration of methylprednisolone in perilymph and plasma of guinea pig. METHODS Infusing typmpanic cavity with methylprednisolone solution,perilymph of the scala tympani and blood were sampled an hour after administrations. Methylprednisolone in the samples was assayed by HPLC. HPLC conditions: ZORBAX Eclipse XDB-C_ 18 column as stationary phase, 7.56 mmol·L~ -1 ammonium sulfate- acetonitrile (68∶32) as mobile phase with the flow rate of 1.0 mL·min~ -1. The temperature of column was at 20 ℃,the wavelength of detection was 243 nm.RESULTS The calibration curve was linear within the concentration range of 0.10- 5.0 mg·L~ -1. An hour after administration, the concentration of methylprednisolone in perilymph of the scala tympani was 2.47 mg·L~ -1,and no methylprednisolone was determined in plasma. CONCLUSION The method is simple,accurate, reproducible and can be used for the determination of the concentration of methylprednisolone in perilymph and plasma." @default.
- W2384239426 created "2016-06-24" @default.
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- W2384239426 date "2005-01-01" @default.
- W2384239426 modified "2023-09-28" @default.
- W2384239426 title "Determination of methylprednisolone in the plasma and scala tympani perilymph of guinea pig after administration by intratympanic infusing" @default.
- W2384239426 hasPublicationYear "2005" @default.
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