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- W2384240069 abstract "Objective To study the inhibitory effect of NNMS on the production of reactive oxygen species in mitochondria during cerebral ischemia and reperfusion. Methods Rats middle cerebral artery ischemia-reperfusion model was induced by intraluminal method. The superoxide anions and hydrogen peroxide produced by mitochondria were monitored with the use of chemiluminescence methods. Before reperfusion, animals were treated with NNMS, the O -· 2, H 2O 2 production level of brain tissue from ischemic area were monitored. Results During 5-40min reperfusion after 2 hours ischemia, mitochondria from ischemic areas produce significantly more O -· 2 and H 2O 2but in NNMS administered groups, it was not different compared with control groups. Conclusion NNMS has the potency to inhibit the production of superoxide anion and hydrogen peroxide in mitochondria during the ischemia and reperfusion." @default.
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- W2384240069 date "2005-01-01" @default.
- W2384240069 modified "2023-09-23" @default.
- W2384240069 title "NNMS reduce the production of ROS after rat cerebral ischemia-reperfusion" @default.
- W2384240069 hasPublicationYear "2005" @default.
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