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- W2384245853 abstract "Objective: To investigate the effects of levocarnitine on nutrition,microinflammation and oxidative stress status in maintenance hemodialysis(MHD) patients.Methods: Sixty-two MHD patients were selected,who had undergone hemodia-lysis for at least three months before the study and were in a stable clinic status without signs of infection or disease.One gram of levocarnitine was infused to the patients at the end of each dialysis treatment for six months.The parameters of microbiology,nutrition,inflammation and oxidative stress were studied.Results: After treatment with levocarnitine for six months,the average levels of dry body weight and mid-arm muscle circumference(MAMC) increased(P0.05),while the score of modified subjective global assessment(SGA) decreased markedly(P0.01).The average serum levels of albumin(P0.05),pre-albumin and hemoglobin(P0.01) were elevated after the treatment.The average serum levels of C-reactive protein(CRP),interleukin 6(IL-6),tumor necrosis factor-α(TNF-α),the average plasma levels of malondialdehyde(MDA) and total homocysteine(tHcy) were significantly lower than those of baseline(P0.01) while the average plasma level of glutathione peroxidase(GSHPx) was elevated markedly(P0.01).Kt/V was kept stable,but protein catabolic rate(PCR) rose significantly(P0.01).Difference was not significant between serum lipid parameters before and after the treatment.Conclusion: Intravenous supplement with levocarnitine in MHD patients appears to be associated with an improvement of nutrition,microinflammation and oxidative stress status." @default.
- W2384245853 created "2016-06-24" @default.
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- W2384245853 date "2006-01-01" @default.
- W2384245853 modified "2023-09-25" @default.
- W2384245853 title "Effects of levocarnitine on microinflammation and oxidative stress status in maintenance hemodialysis patients" @default.
- W2384245853 hasPublicationYear "2006" @default.
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