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- W2384249373 abstract "Objective: To observe the regulating effects of NO on cyclic adenosine monophosphate and cyclic guanosine 3, 5-monophosphate (cAMP, cGMP) in kidneys of neonatal rats with endotoxic shock. Methods: 180 seven-day newborn Wistar rats were randomly divided into 3 groups. Group A (control group): animals were injected intraperitoneally with the same volume (0.1ml) of 0.9% sodium chloride as the other 2 groups. Group B (LPS group): animals were injected by a single bolus of lipopolysaccharide (LPS 5 mg/kg). Group C (Dex group): animals received LPS 5 mg/kg+Dxe10 mg/kg. At the designed time point (0, 2, 4, 6, 24 h) ten newborn rats were killed and kidneys were collected for assay. The content of NO in kidneys were measured by colorimetric analysis. The levels of cAMP and cGMP were measured by radioimmunoassay. Blood gas analysis was dynamicly observed and mortality of rats at 24-hour in each group was recorded. Results: In group B, the concentration of NO, cAMP and cGMP of the kidneys were all higher than that of group A from 2 hours to 24 hours (P 0.01); in group C, the concentration of NO was also higher than that of group A at 2 hours (P 0.05), but the value was lower than group B at 24 hours(P 0.05); the content of cAMP was also higher than that of group A and B from 2 hours to 24 hours (P 0.01), the cGMP value peaks at 2 hours (P 0.01), and then gradually decreased to the lower level than the group B at 24 hours (P 0.01); Blood gas analysis showed metabolic acidosis with respiratory alkalosis and hypoxycemia in the rats of endotoxic shock at 24 hours. Mortality of group B was higher than that of group A at 24 hours (50%, 30%, P 0.05). Conclusions: The study suggests that LPS stimulate the newborn rat kidneys to create excessive NO and more cAMP and cGMP, giving rise to abnormality of blood gas analysis and higher mortality of newborn rat with endotoxic shock. Dex can protect kidneys from damage by regulating the NO- second messenger system in endotoxic shock of neonates, and reduce the mortality." @default.
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- W2384249373 date "2004-01-01" @default.
- W2384249373 modified "2023-09-23" @default.
- W2384249373 title "Regulation of NO on cAMP and cGMP in kidneys of neonatal rats with endotoxic shock" @default.
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