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- W2384251772 abstract "Objective: This study was designed to evaluate the extent of vancomycin removal from the blood compartment during extended daily dialysis(EDD).Methods: Eight ICU patients were selected.They all had oliguric acute renal failure requiring EDD and were on vancomycin therapy.The blood flow rate and dialysate flow rate are fixed at 180 ml/min and 150 ml/min respectively.Blood samples were drawn at 0,2,4,and 8 hours to determine the extent of reduction in vancomycin level.Results: The total reduction of vancomycin was about 37% with an 8-hour treatment,when following a typical EDD prescription.Drug removal was greatest during the first 4 hours(29.0±7.2)% compared to the last 4 hours(11.8±5.2)% of EDD(P0.05).Conclusion: EDD patients maybe at risk for undertreatment of their infections.A redosing strategy should be considered if the estimated or measured predialysis level is 20-30 μg/ml.Therapeutic drug monitoring is still an essential part of any dosing scheme." @default.
- W2384251772 created "2016-06-24" @default.
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- W2384251772 date "2010-01-01" @default.
- W2384251772 modified "2023-09-24" @default.
- W2384251772 title "Removal of vancomycin in extended daily dialysis" @default.
- W2384251772 hasPublicationYear "2010" @default.
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