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- W2384251969 abstract "Objective To explore the influence of Fluvastatin on bone morphogenetic protein-7 (BMP-7) in the process of fracture healing of rats with osteoporosis. Methods 96 female SD rats aged six-month old were randomly divided into two groups: bilateral ovariectomized group (48 cases) and pseudo-operated group (48 cases). Three months later, fracture model was made on the mid-femoral in bilateral ovariectomized group, which were then randomly divided into administration group (24 cases, given 10 mg·kg~-1 ·d~-1 Fluvastatin, 2 weeks) and control group (24 cases, given placebo). The expression of BMP-7 and BMP-7 mRNA in the bone callus of both groups was examined by immunohistochemical method and hybridization in situ on the 3rd, 7th, 14th, 21st, 28th and 42nd days in healing process. Meanwhile image analysis was conducted with the color image analytical tool. Results There was no difference between two groups in the cellular localization of the expression of BMP-7 and BMP-7 mRNA gene with basically similar expression model. But after 14 days, the positive level of positive cell of the administration group was stronger than that of control group (P0.05). Conclusions Fluvastatin should have certain promotive effect on bone morphogenetic protein-7 (BMP-7) in the process of fracture healing of rats with osteoporosis." @default.
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- W2384251969 date "2005-01-01" @default.
- W2384251969 modified "2023-09-23" @default.
- W2384251969 title "Influence of Fluvastatin on bone morphogenetic protein-7 in the process of fracture healing of rats with osteoporosis" @default.
- W2384251969 hasPublicationYear "2005" @default.
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