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- W2384254755 abstract "Objective To investigate the expression of calpain 6 in cervical intraepithelial neoplasia(CIN) and cancer of the cervix(CC) and analyze its association with microvessel density(MVD). Methods Calpain 6 expression was observed byusing immunohistochemistry PV-9000 technique and MVD counted in 10 cases of normal cervical epithelium(NCE),30 of CIN,and 65 of CC. Results The positive rates of calpain 6 expression in NCE,CIN and CC gradually increased(H=30.05,P0.01).The expression was significantly higher in patients with cancer at late FIGO stage,with poor differentiation and lymph node metastasis than that in patients at early stage,with good differentiation and without lymph node metastasis(χ2=4.068-9.524,P0.05).The expression of calpain 6 had no significant association with patient's age and histology type,but was positively correlated with MVD(r=0.946,P0.01). Conclusion The results suggested that calpain 6 enhances tumor growth,infiltration and metastasis via an increase of tumor neovascularity." @default.
- W2384254755 created "2016-06-24" @default.
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- W2384254755 date "2010-01-01" @default.
- W2384254755 modified "2023-10-05" @default.
- W2384254755 title "EXPRESSION OF CALPAIN 6 IN TISSUE OF CANCER OF THE CERVIX AND ITS RELATIONSHIP WITH MICROVESSEL DENSITY" @default.
- W2384254755 hasPublicationYear "2010" @default.
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