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- W2384259202 abstract "Objective The phenotypes of the T、B lymphocyte subpopulation in myasthenic thymus were studied and the correlation of the peripheral blood(PB) and thymus were analyzed. Methods The immunofluorescence labeling technique was adopted to detect the phenotypes of the lymphocyte subpopulation in the peripheral blood (PB) of 59 myasthenia gravis (MG) patients including 30 cases with the thymus involved and the thymus and PB of 8 cases after cell culture in vitro via the flow cytometry were assayed. Results T helper cell (Th, CD4 +) in all MG patients were abnormally higher, even higher in those course lasted no more than six months and those with thymic hyperplasia.(2)The activated Th cells (CD4 +/CD25 +) were significantly increased in both myasthenic thymus and PB and CD5 - B cells (CD5 - /CD19 +) were increased in the myasthenic thymus after the stimulation of acetylcholine receptor (AChR) in vitro. In addition, the CD5 - B cells in PB of MG patients were correlated with their own serum acetylcholine receptor antibody (AChRAb) titer. After thymectomy (Tx), CD4 +/CD25 + and cells in the thymus and PB were decreased to some extent. Conclusion There are abnormal phenotypes of AChR specific responding T、B cell subpopulation in the myasthenic thymus, especially the activated Th cells. In addition,CD5 - B cells might be related to the pathogenesis of the MG." @default.
- W2384259202 created "2016-06-24" @default.
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- W2384259202 date "2000-01-01" @default.
- W2384259202 modified "2023-09-25" @default.
- W2384259202 title "The Changes of the Phenotypes of the Lymphocyte Subpopulation in Myasthenic Thymus" @default.
- W2384259202 hasPublicationYear "2000" @default.
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