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- W2384270294 abstract "Objective To research the inhibitory effects of As 2O 3 on the function of immune system in mice and the antagonistic effects of organic selenium and polysacchrides.Methods Kunming mice were randomly divided into 6 groups.The mice in control group were given saline 0.2ml/d.The mice in group 2 to 4 were given As 2O 3 at dose 1.15mg/kg、2.3mg/kg、4.6mg/kg ig respectively.In the selenium group,organic selenium was given to mice at dose 0.1mg/kg,and As 2O 3 2.3mg/kg ig.The mice in group 6 were treated with organic selenium 0.1mg/kg,Hericium erinaceus polysacchrides (HEPS) 100mg/kg and As 2O 3 2.3mg/kg ig.The content of hemolysin was determined using colorimetric method in the 7th day after treatment.The effect on the function of reticuloendothelial system in mice was tested with carbon clearance test in the 10th day after medication.Results The results showed that As 2O 3 at dose 1.15mg/kg、2.3mg/kg、4.6mg/kg could significantly inhibit the production of hemolysin(P0.05),and As 2O 3 could also inhibit the function of reticuloendothelial system in mice (P0.05).Selenium 0.1mg/kg and HEPS 100mg/kg showed antagonistic effects to As 2O 3.Conclusions As 2O 3 could inhibit the immune function of mice,but organic selenium and HEPS at certain doses could antagonize those effects. [" @default.
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- W2384270294 title "The immunological effects of As 2O 3 on mice" @default.
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