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- W2384275280 abstract "Objective To investigate the anticancer effect of HCPT combined with hyperthermia on human gastric adenocarcinoma cell lines SGC-7901 and BGC-823. Methods The working concentrations of HCPT against gastric cancer cell lines were determined by MTT assay that has been developed for quantitative evaluation of the proliferation of cells. Then hyperthermia and chemotherapy were used singly or concurrently and the cell survival rates were obtained at 24 h or 48 h. The anticancer effect was evaluated by Veleriote method. The apoptosis rates of BGC-823 were determined at 24 h by flow cytometric analyses. Results The concentrations were defined as those of IC20～IC30 at 24 h. They both turned out to be 3 μg/mL. 43 ℃ hyperthermia 60 min showed obvious inhibition to the two cell lines at 24 h (P0.05), but it did not at 48 h. HCPT showed obvious inhibition to SGC-7901 at 24 h (P0.01), and it did at 24 h and 48 h when it was combined with hyperthermia at 43 ℃ for 60 min (P0.01). HCPT 3 μg/mL combined with hyperthermia showed obvious synergism to SGC-7901 at 24 h and 48 h. HCPT chemotherapy or hyperthermia both obviously inhibited the growth of BGC-823 at 24 h and 48 h(P0.01). HCPT 3 μg/mL combined with hyperthermia showed subaddictive effect to BGC-823 at 24 h and obvious synergism at 48 h. According to flow cytometric analyses at 24 h, hyperthermia and HCPT singly or concurrently could obviously increase the apoptosis rates of BGC-823 (P0.05). Conclusions HCPT 3 μg/mL combined with 43 ℃ hyperthermia 60 min showed obvious synergism to SGC-7901 at 24 h and 48 h. And HCPT 3 μg/mL combined with hyperthermia showed subaddictive effect to BGC-823 at 24 h and obvious synergism at 48 h. The synergism might relate to the increase of cell apoptosis rates." @default.
- W2384275280 created "2016-06-24" @default.
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- W2384275280 date "2005-01-01" @default.
- W2384275280 modified "2023-09-23" @default.
- W2384275280 title "THE SUPPRESSION EFFECT OF HYDROXYCAMPTOTHECINE COMBINED WITH HYPERTHERMIA ON HUMAN GASTRIC ADENOCARCINOMA CELL LINES IN VITRO" @default.
- W2384275280 hasPublicationYear "2005" @default.
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