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- W2384277368 abstract "Chronic elevation in markers of immune activation is a hallmark of HIV infection, even when viral replication has been suppressed by antiretroviral therapy (ART) (Lederman et al., 2013). The Strategies for the Management of Antiretroviral Therapy (SMART) study demonstrated that plasma levels of interleukin-6 (IL-6), C-reactive protein, and D-dimer are independent predictors of mortality in HIV infection, including deaths related to cardiovascular disease (CVD) (Kuller, LH, et al., 2008, Emery, S, et al., 2008). The predictive value of markers of immune activation and inflammation has been confirmed in several studies (Psomas, C, et al., 2016, Hunt, PW, et al., 2014, Kalayjian, RC, et al., 2010). Potential mechanisms have also been identified that may contribute to increased activation of both the innate and the adaptive immune systems in chronic HIV infection, including: copathogens, microbial translocation, pro-inflammatory lipids, low level viral replication, and the immune system's response to cytopenia (Lederman et al., 2013)." @default.
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- W2384277368 date "2016-06-01" @default.
- W2384277368 modified "2023-10-15" @default.
- W2384277368 title "Identification of Immune Activation Profiles That May Predict Morbidity During Antiretroviral Therapy Treated HIV Infection" @default.
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- W2384277368 doi "https://doi.org/10.1016/j.ebiom.2016.05.012" @default.
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