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- W2384277517 abstract "An anti-tumour strain JXJ-0108 was screened out from 150 actinomycetes strains by detecting deformation of mycelia of Pyricularia Oryzae,and compound JXJ-0108-1,which showed strong anti-tumour activity and taked on potential value in the development of anti-gastric cancer and hepatoma drugs,was purified from the fermentation liquid.The antitumor activity of the compound was examined by MTT(Microculture Tetrozolium) method in vitro,and the IC50 values on human hepatic carcinoma cells BEL-7402 and gastric carcinoma cells BGC-823 were 1.63 and 0.95 ug/mL,respectively.Compared with the control groups,the proportions of hepatic carcinoma cells BEL-7402 and gastric carcinoma cells BGC-823 in G0/G1,S and G2/M phases presented very notable difference after treated with the compound from the concentrations of 0.50 and 0.30 ug/mL,respectively.As the results,the proportions of cells in G0/G1 and S phases were reduced,while the proportion of cells in G2/M phase was increased.This paper provides a quick and convenient method to screen anti-tumour actinomycetes and track the active compounds during the purification efficaciously." @default.
- W2384277517 created "2016-06-24" @default.
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- W2384277517 date "2012-01-01" @default.
- W2384277517 modified "2023-09-23" @default.
- W2384277517 title "Screening of Anti-tumour Actinomycete Using Conidia of Pyricularia Oryzae" @default.
- W2384277517 hasPublicationYear "2012" @default.
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