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- W2384280159 abstract "Objective To investigate the application value of C-12 protein biochip detective system in the diagnosis of digestive tract malignancies.Methods The expression of twelve tumor markers in serum were detected by protein biochip technology in 283 cases of malignant tumor of digestive tract cancer,186 cases of benign digestive diseases and 421 cases of normal control.Results The positive ratio of 77.74% in the malignant tumor group was significantly higher than that of the benign diseases group(35.48%,P0.01) and the normal control group(22.09%,P0.01).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of the protein biochip system were 77.74%,73.81%,75.06%,58.05%,and 87.67%,respectively.The positive ratio of combined detection was significantly higher than that of single tumor maker(P0.05),but its positive ratio of 30.16% for staging Ⅰ and Ⅱ digestive tract cancer was still relatively low.The expression of tumor markers CEA,CA19-9,CA242,CA15-3,CA125 and ferrtin in digestive tract cancer was markedly stronger than the others(P0.05).Conclusions The effect of C-12 protein biochip detection system on illness monitoring and prognosis judgment was better than that on diagnosis,but it had less sensitivity for the early diagnosis of digestive tract cancer.It is preferable that the existing indicators be optimized and combined according to the latest achievements of the researches on serum tumor markers in recent years and that a specific,digestive tract cancer-targeted protein biochip be designed so as to improve the detection effectiveness and the accuracy of early diagnosis of malignant tumors of the digestive tract." @default.
- W2384280159 created "2016-06-24" @default.
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- W2384280159 date "2009-01-01" @default.
- W2384280159 modified "2023-09-23" @default.
- W2384280159 title "The application value of C-12 protein biochip detective system in the diagnosis of digestive tract malignancies" @default.
- W2384280159 hasPublicationYear "2009" @default.
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