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- W2384291427 abstract "Objective:To observe the influence of drug serum of BuShen JianPi prescription(BSJP) combinating with 5-Fluorouracil on inhibiting cell proliferation and increasing cell apoptosis of human hepatoma cell line HepG2. Methods:According to the serum pharmacology of chinese medicine,we got the prescription of BSJP drug serum,5-fluorin pyridine(5-FU serum group)and combination drug serum group of BSJP and 5-FU. The three drug serum groups were used to culture HepG2 separately in vitro, and the tumor cell proliferation were observed,the tumor cell proliferating cycle and apoptosis rate were measured. Result:Drug serum of BSJP and 5-FU could inhibit the proliferation of HepG2,and stuck tumor cell proliferation in the G0/G1 phase of cell cycle. The apoptosis of tumor cells were also promoted by the drug serum significantly. Capacity of inhibiting proliferation and increasing apoptosis of the drug serum produced by the combination of BSJP and 5-FU was further strengthen,which show a certain degree of synergism. Conclusion:Drug serum of BSJP and 5-FU could inhibit the proliferation of HepG2 and promote apoptosis of HepG2.The combined application of BSJP and 5-FU could alleviate the inhibitory effect." @default.
- W2384291427 created "2016-06-24" @default.
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- W2384291427 date "2010-01-01" @default.
- W2384291427 modified "2023-09-23" @default.
- W2384291427 title "Affection of Drug Serum of BuShen JianPi Rescription and 5-Fluorouracil Combination on Proliferation and Apoptosis of Human Hepatoma Cell Line HepG2" @default.
- W2384291427 hasPublicationYear "2010" @default.
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