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- W2384292262 abstract "AIM: To investigate the expression of nuclear factor-kappa B (NF-кB) and survivin in epithelial ovarian tumor and to study their correlation. METHODS: The expression of NF-кB p65 and survivin in 104 specimens of epithelial ovarian tumor was examined by SABC immunohistochemical staining. RESULTS: The positivity rates of NF-кB p65 of epithelial ovarian malignant tumors, borderline tumors, benign tumors and normal ovarian tissues were 71%, 44%, 40% and 0% respectively. The NF-кB p65 protein expression in malignant tumors was significantly higher than that in benign tumors and normal tissues (P0.01). The expression of NF-кB p65 was positively correlated with the histological grade and clinical stage (P0.05). High expression of NF-кB p65 was related to the lymph node metastasis of ovarian cancer (P0.05). The positivity rates of survivin in epithelial ovarian malignant tumors and borderline tumors were 65% and 61%, respectively, significantly higher than those in the benign tumors and normal tissues (P0.05). High expression of survivin was related to the clinical stage and lymph node metastasis of ovarian cancer (P 0.05). Positive NF-кB expression was strongly correlated with survivin expression (P0.05). CONCLUSION: NF-кB and survivin may be useful markers for carcinogenesis and progression of malignant ovarian tumors, with close relation each other." @default.
- W2384292262 created "2016-06-24" @default.
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- W2384292262 date "2005-01-01" @default.
- W2384292262 modified "2023-09-27" @default.
- W2384292262 title "Expression and correlation of nuclear factor-kappa B and survivin in epithelial ovarian tumor" @default.
- W2384292262 hasPublicationYear "2005" @default.
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