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- W2384293316 abstract "Objective To study the expression of thrombopoietin (TPO) and its receptor mRNA (C-mpl-mRNA) in multiple myeloma (MM), and to study the correlation between them and the clinical stages. Methods Thirty-four multiple myeloma patients were divided into 3 groups by Durie-Solmon, the stage Ⅰ(A), the stage Ⅱ(B) and the stage Ⅲ(C). The contents of TPO and the mRNA levels of C-mpl in platelets were measured by ELISA and reverse transcriptase polymerase chain reation before and after chemotherapy. Results The TPO and c-mpl mRNA expression levels in patients were significantly higher than those in control group (P 0.05); those in stage Ⅲ was significantly higher than those in stage Ⅰ and stage Ⅱ (P 0.05); those in stage Ⅰ was not significantly different from those in stage Ⅱ, those in patients were correlated positively with the clinic stage (r= 0.423, 0.436,P 0.05), and decrease significantly after chemotherapy (P 0.05). Conclusion The levels of TPO and c-mpl mRNA expression in patients can be used to reflect the pathological degree of multiple myeloma. and decreased after chemotherapy." @default.
- W2384293316 created "2016-06-24" @default.
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- W2384293316 date "2005-01-01" @default.
- W2384293316 modified "2023-09-23" @default.
- W2384293316 title "Expression of thrombopoietin and its receptor mRNA in multiple myeloma" @default.
- W2384293316 hasPublicationYear "2005" @default.
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