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- W2384293750 abstract "Objective:To detect the expression of human stanniocalcin-1(hSTC-1) mRNA in peripheral blood and tumor tissues of breast cancer patients,determine micrometastases in peripheral blood,and study the relationship between the micrometastases and malignant degree of breast cancer.Methods:The expression of hSTC-1 mRNA in peripheral blood and breast cancer tissues was detected by RT-PCR.The expression of estrogen receptor(ER),progesterone receptor(PR),and vascular endothelial growth factor(VEGF) in breast cancer tissues were detected by immunohistochemical method.Results:Expression of hSTC-1 mRNA was identified in breast cancer tissues from 28 of 30 patients(93.3%) and in peripheral blood from 19 of 51 patients(37.3%).Expression of hSTC-1 mRNA was not detected in the peripheral blood from 17 women without breast cancer.Expression of hSTC-1 mRNA in the peripheral blood significantly correlated with multiple clinicopathological factors(P0.05),including tumor size,metastasis of lymph nodes,TNM stage,and the expression of ER and VEGF.Conclusion:The expression of hSTC-1 mRNA in the peripheral blood of breast cancer patients suggests the occurrence of micrometastasis.It significantly correlates with multiple clinicopathological factors which determined the prognosis of breast cancer.So hSTC-1 is proposed as a new marker for detecting micrometastasis of breast cancer in the peripheral blood." @default.
- W2384293750 created "2016-06-24" @default.
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- W2384293750 date "2007-01-01" @default.
- W2384293750 modified "2023-09-23" @default.
- W2384293750 title "Expression of hSTC-1 gene in peripheral blood and its correlation with micrometastases of breast cancer" @default.
- W2384293750 hasPublicationYear "2007" @default.
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