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- W2384293876 abstract "Objective To establish brain glioma models of C6 cells with different methods in rats and to observe the characteristics of the tumors growth. Methods Rat C6 glioma cells were cultured in vitro. Ten μl of cell suspensions containing 1.0×105 C6 cells/10μl, 1.0×106 C6 cells/10μl and 1.0×107 C6 cells/10μl was stereotaxically inoculated into the right caudate nucleus of the brain in the rats of different experimental groups, respectively. The moving and survival states of rats with gliomas were observed. The examinations of the tumors formation, volumes, metastasis and histopathology were performed. The expression of glial fibrillary acidic protein(GFAP), and vascular endothelial growth factor(VEGF) in the tumors were determined by immuohistochemistry. Results All the rats receiving inoculation of different dose of C6 cells developed brain tumors without extracranial metastasis. The rat C6 gliomas resembled histopathologically human glioma. The tumors contained many cells with remarkable cytoplasmic and nuclear polymorphism, and pathological mitosis figures. The scattered positive expression of VEGF was observed in tumor cells. There was the strongly positive expression of GFAP in the tumors. Conclusions The successful rate of C6 brain tumor model established by the intracerebral inoculation of C6 cells is very high in rats. The tumor established in the experiment is similar to human glioma in histopathological features and it can be used as a good model to study the glioma. The tumors model established by inoculation of different dose of C6 cells can be selected according to different needs of different experiments because their growth speeds are different from each other." @default.
- W2384293876 created "2016-06-24" @default.
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- W2384293876 date "2006-01-01" @default.
- W2384293876 modified "2023-09-26" @default.
- W2384293876 title "Establishment of Cell Line C6 Brain Glioma Models in Rats" @default.
- W2384293876 hasPublicationYear "2006" @default.
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