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- W2384296600 abstract "abstractjective: To study the effect of angiostatin gene on cell proliferation of colon carcinoma and tumor angiogenesis in vivo, and discuss the inhibitive effect of angiostatin gene on colon carcinoma. Methods:Reconstructing plasmid pc DNA3. 1(+)angio was constructed, then the plasmid and blank vector were transducted into colon carcinoma cells by lipofection mothod. Cell growth curve was drawn and proliferation-inhibiting rate was calculated after cell culture. Then pcDNA3. 1 ( + )/angio, pcDNA3. 1( + )/Colo205, Colo205 were respectively inoculated into hypoderm of right-sided nuchae of nude mice. Tumor growth speed was observed, tumor volume was calculated, and microvascular density (MVD) and expression of VEGF were checked by immunohistochemistry. Results:In vitro, cell growth speed of pcDNA3. 1( + )/angio group was slower than that of pcDNA3. 1 ( + )/Colo205 group and Colo205 group, but there was no statistic significance ( P0. 05). In vivo, carcinogenic potence of the pcDNA3.1( + )/angio group was lower, growth speed of tumor tissue was lower and tumor-inhibiting rate was higher ( P 0. 01), and MVD and VEGF expression in the tumor tissue were lower than the other two groups (P 0. 05). The difference between pcDNA3.1( + )/Colo205 group and Colo205 group was not significant ( P 0. 05). Conclusion: Angiostatin has no effect on biologic property of Colo205 directly in virto, while it can inhibit tumor growth evidently in vivo, the mechanism of which may be related to inhibiting tumor angiogenesis by decreasing VEGF." @default.
- W2384296600 created "2016-06-24" @default.
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- W2384296600 date "2004-01-01" @default.
- W2384296600 modified "2023-09-26" @default.
- W2384296600 title "fect of Angiostatin Gene on Inhibiting Cell Proliferation of Colon Carcinoma and Tumor Angiogenesis" @default.
- W2384296600 hasPublicationYear "2004" @default.
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