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- W2384298897 abstract "Objective:To observe the effect of triptolide on the activation of nuclear factor-κB(NF-κB)and the expression of monocyte chemoatractant protein-1(MCP-1)caused by AngiotensinⅡ(AngⅡ)in the rats' mesangial cells(GMC).To investigate the possible mechanism of the inhibiting effect of triptolide in the expression of the inflammatory factor in GMC.Methods:GMC were extracted from healthy SD rats,culture and passage the cells.Divide the GMC into five groups:(1)control group(2)AngⅡ group(3)3 doses of triptolide groups.Using laser scanning confocal microscopy to observe the expression of inflammation correlation factor NF-Kb p65.The protein level of MCP-1 in the supernatant of GMC is measured by ELISA assay.The protein level of Iκ-B was detected by western blot analysis.The mRNA expressions of MCP-1 was measured by reverse transcription polymerase chain reaction(RT-PCR).Results:Triptolide can inhibit the excessive expression of the protein and mRNA of MCP-1 and the overacfivity of NF-κB in GMC which are induced by the Ang.It also can increase the protein level of IκBα which was down-regulated by the AngⅡ.Conclusion:Triptolide can inhibit both phosphorylation degradation of the IκB and the activation of the NF-κB in rat's GMC which was induced by the Ang.Triptolide also can down-regulate both the protein and mRNA expression level of MCP-1.It indicated that the triptolide might be able to reduce the monocytic infiltration in the GMC and down-regulate the inflammatory reaction level in the GMC." @default.
- W2384298897 created "2016-06-24" @default.
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- W2384298897 date "2007-01-01" @default.
- W2384298897 modified "2023-09-25" @default.
- W2384298897 title "The Effect of Triptolide in Regulating the Angiotensin Induced Activation of Nuclear Factor-κB and the Excessive Expressions of the Monocyte Chemoattractant Protein-1 in Rat's Mesangial Cells" @default.
- W2384298897 hasPublicationYear "2007" @default.
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