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- W2384299737 abstract "Objective To evaluate the efficacy of Lifein combined with gemcitabine and cisplatine( GC) chemotherapy for advanced bladder urothelial carcinoma carcinoma. Methods 83 patients with bladder urothelial carcinoma were randomly divided into experimental group( n = 39) and control group( n = 44). Patients in the control group were given GC chemotherapy: Intravenous drip of Gemcitabine 1 000 mg / m2,d1,d8 and d15; Cisplatine 30 mg/m2,d1 ~3. Patients in the control group were given Lifein beside GC. Intravenous drip of Lifein 20 mg and saline 100 ml once a day for 21 days. The clinical efficacy,KPS,and side effects were observed in two groups. Results After two treatment cycles,there was 5 complete remission( 11. 9%),16 partial remission( 38. 1%),13 stable disease( 31. 0%) and 8 progression disease( 19. 0%) in the control group; and in the experimental group,there was 6 CR( 15. 4%),20 PR( 51. 3%),10 SD( 25. 6%) and 3 PD( 7. 7%). The overall rate of curative effect of experimental group( 66. 7%) was higher than that of control group( 50. 0%),but there was no significant difference. Patients with increased KPS after treatment in the experimental group( 34 /39) were significantly more than those( 28 /42) of control group( P = 0. 037). There was less myelosuppression,Ⅲ ~ Ⅳ degree reduction of leukocyte( P = 0. 006) and deferred cycles in the experimental group( P = 0. 001). Conclusion Lifein has therapeutic effect on bladder urothelial carcinoma,and can reduce myelosuppression and other side effects caused by chemotherapy. The combination of Lifein and GC is a promising treatment for advanced bladder urothelial carcinoma." @default.
- W2384299737 created "2016-06-24" @default.
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- W2384299737 date "2014-01-01" @default.
- W2384299737 modified "2023-09-28" @default.
- W2384299737 title "The Clinical Observation of Lifein plus Gemcitabine and Cisplatine for Bladder Cancer" @default.
- W2384299737 hasPublicationYear "2014" @default.
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