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- W2384301344 abstract "Objective To study the change and the effects of the Ginkgo leaves extract on the activation of platelet in patients with chronic cor pulmonale during acute period.Methods 40 patients with chronic cor pulmonale during acute period were selected and randomly divided into 2 groups.20 patients in routine treatment group were treated by routine therapy; the other 20 patients in Ginkgo leaves extract treatment group were treated by routine therapy combined with Ginkgo leaves extract. Besides, 20 healthy subjects were selected as control group. Before and after treatment intracellular calcium and a granule protein of surface (CD62p) of platelet were examined by flow cytometry, and the levels of serum NO were measured by biochemistry.The changes of these indexes mentioned above were observed.Results The platelet intracellular calcium and the CD62p in all the patients with chronic cor pulmonale during the acute period were significantly higher than those of control group (P0.01),the levels of serum NO were obviously lower than those of control group (P0.01).After treatment the platelet intracellular calcium and CD62p in patients were lower than those before treatment (P0.01),NO was higher than that before treatment (P 0.01) both in routine treatment group and the Ginkgo leaves extract treatment group. After treatment the changes ofplatelet intracellular calcium,CD62p and levels of serum NO were significant different between routine treatment group and the Ginkgo leaves extract treatment group (P0.01).Conclusions The activated platelet may be involved in pathogenesis of chronic cor pulmonale,the Ginkgo leaves extract includes the inhibiter of PAF that can inhibit platelet aggregation effectively, decrease the information of embolism in patients with chronic cor pulmonale." @default.
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- W2384301344 date "2007-01-01" @default.
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- W2384301344 title "Effect of the Ginkgo leaves extract on platelet activation in the patients with chronic cor pulmonale during acute period" @default.
- W2384301344 hasPublicationYear "2007" @default.
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