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- W2384306913 abstract "【Objective】 To study the changes of serum NGF concentration in infants with congenital hypothyroidism(CH) before and after replacement therapy with L-thyroxine(L-T_4),and it's relation to FT_4. 【Methods】 Serum NGF concentration was measured by enzyme linked immunosorbent assay(ELISA) and serum FT_3、FT_4、TSH concentration was measured by electrochemiluminoimmunoassay(ECLIA)in 35 infants with CH before and after successful L-thyroxine(L-T_4) replacement therapy,and 35 normal controls that age、sex matched with CH patients respectively.Statistical analyses were carried out with SPSS10.0 for windows using simple correlation. 【Results】 ①Surum NGF concentration correlae with FT_4,but had no linear correlation.The range of surum NGF concentration changes in CH group were significantly lower than normal control group.②Serum NGF concentration was higher in clinical CH than in mild CH infants before treatment,but no difference in them after treatment. 【Conclusions】 These results suggest that surum NGF is affected by FT_4,surum NGF concentration cut down due to the deficiency of FT_4,ectogenic thyroxine can raise serum NGF concentration in CH patients." @default.
- W2384306913 created "2016-06-24" @default.
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- W2384306913 date "2006-01-01" @default.
- W2384306913 modified "2023-09-23" @default.
- W2384306913 title "Study of serum NGF and it's relation to FT_4 in infants with congenital hypothyroidism." @default.
- W2384306913 hasPublicationYear "2006" @default.
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