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- W2384307100 abstract "OBJECTIVE To study the relative bioequivalence of mitiglinide capsule and mitiglinide tablet in Chinese healthy volunteers.METHODS A single dose of 10 mg mitiglinide was randomly administrated to 20 healthy volunteers in two-way cross-over design.Plasma concentration of mitiglinide was determined by LC-MS method.Pharmacokinetic parameters were calculated.The bioequivalence of the two preparations was calculated by analysis variance and two one side t-test.RESULTS After oral administration,the main pharmacokinetic parameters of test and reference preparations were as follows:t1/2(1.2±0.3)h and(1.1±0.3)h,tmax(0.6±0.2)h and(0.5±0.3)h,Cmax(838.4±226.6)μg·L-1 and(947.3±230.9)μg·L-1,AUC0-12(1 354.0±308.4)ng·h·mL-1 and(1 298.8±376.4)ng·h·mL-1.CONCLUSION The two preparation were bioequivalent." @default.
- W2384307100 created "2016-06-24" @default.
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- W2384307100 date "2010-01-01" @default.
- W2384307100 modified "2023-09-28" @default.
- W2384307100 title "Bioavailability of mitiglinide calcium capsule in Chinese healthy volunteers" @default.
- W2384307100 hasPublicationYear "2010" @default.
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