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- W2384309797 abstract "Objective To observe the expression of Bcl-2 and bax in brain tissue of the middle cerebral artery occlusion/reperfusion(MCAO/R) model,when given Granulocyte-Colony Stinulating Factor(G-CSF) treatment.And to explore neuroprotective effect of G-CSF and its mechanism.Methods 36 adult healthy male SD rats were randomly divided into sham-operated group,vehide group and G-CSF treatment group.Infarct volume was measured by triphenyltetrazolium chloride staining.TUNEL technique was carried out to detect the changes of apoptotic cell.The expressions of bcl-2 and bax in brain tissues were measured by immunohistochemical methods and their gray value was measured by imaging analysis system.Results Compared with the control group,Infarct volume was smaller(P0.05),apoptotic cells were decreased(P0.05),The expression of bax was decreased(P0.05),the expression of bcl-2 was increased(P0.05) in the G-CSF treatment group.Conclusions G-CSF treatment may inhibit apoptosis of neurol cells caused by the ischemia-reperfusion injury.This maybe one of the neuroprotective mechanism of G-CSF." @default.
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- W2384309797 date "2011-01-01" @default.
- W2384309797 modified "2023-09-24" @default.
- W2384309797 title "Effects of Granulocyte-Colony Stinulating Factor on Expression of Bcl-2 and Bax in Rats with Focal Cerebral Ischemia Reperfusion" @default.
- W2384309797 hasPublicationYear "2011" @default.
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