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- W2384309840 abstract "Objective To compare the DNA ploidy and cell cycle distribution of human nasopharyngeal carcinoma subclones F 1 and S 1 with different radiosensitivity, and to study the relationship of radiosensitive heterogeneity with DNA ploidy and cell cycle distribution. Methods Cell culture and nude mice experiment in vivo were used, F 1, S 1 and nude mice transplanted tumors were analyzed for DNA ploidy and cell cycle distribution by feulgen staining and image analysis.Results F 1, S 1 and xenografts were aneuploidy. DNA content, 5C and 5C of F 1were higher than those of S 1 (P0.01). 3-4C in F 1 and transplanted tumors were lower than in S 1 groups (P0.01). G 2/M phase of F 1 and transplanted tumors were both higher than those of S 1 groups, G 0/G 1 phase of F 1 and transplanted tumors were lower than those of S 1 groups (P0.01-0.05). S phase of F 1 cell was lower than of S 1 cell(P0.01).Conclusion F 1 presented higher DNA content, wider ploidy distribution and shifted to right with more cells in G 2/M phase which was sensitive to radiation, S 1 presented lower DNA content, narrower ploidy distribution with more cells in G 0/G 1 and S phase. Different distribution of DNA ploidy and cell cycle may be one of the reasons of different radiosensitivity with F 1 and S 1." @default.
- W2384309840 created "2016-06-24" @default.
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- W2384309840 date "2004-01-01" @default.
- W2384309840 modified "2023-09-23" @default.
- W2384309840 title "Distribution of DNA ploidy and cell cycle in nasopharyngeal carcinoma cells with different radiosensitivity" @default.
- W2384309840 hasPublicationYear "2004" @default.
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