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- W2384312162 abstract "The effect of florfenicol(FFC)on the activity of cytochrome P450 2E1(CYP2E1)in Carassius auratus was e- valuated by pharmacokinetics using chlorzoxazone(CZX)as a specific substrate.FFC was administered orally for 5 days at 100 mg·(kg·d)~(-1)for the experimental group.Control fish received an equal volume of normal saline only.On day 6, fish were given an intraperitoneal injection with 10 mg·kg~(-1)CZX.The plasma concentrations of CZX were determined by HPLC.The pharmacokinetic parameters were calculated.The results showed that the concentration-time data of CZX in two groups were both fitted two compartment model.Compared with the saline-treated control group,elimination half life was increased by 5 fold(P0.01),area under the curve was increased by 3.3 fold(P0.01),and total clearance was shortened by 83.8%(P0.01)in the FFC-treated group.The results indicated that the activity of CYP2E1 could be markedly inhibited by FFC.Efficacy and safety profiles of a drug may be affected when concomitantly used with this drug." @default.
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- W2384312162 date "2007-01-01" @default.
- W2384312162 modified "2023-09-23" @default.
- W2384312162 title "Study on effect of florfenicol on cytochrome P450 2E1 activity in Carassius auratus using pharmacokinetic method" @default.
- W2384312162 hasPublicationYear "2007" @default.
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