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- W2384320370 abstract "Objective:To investigate the expression and the significance of TGF-β1 and IGF-Ⅰ in the chondrocyte of OA model in rabbit.Methods:There were forty New Zealand rabbits,they were randomly divided into experiment group and control group.There were twenty in each group.The model of OA was established with Hulth's method in experiment group,the rabbits of control group received unilateral knee arthrotomy.There were ten rabbits were killed in each group at four and eight weeks after the operation.H-E stains were adopted.The expression of TGF-β1 and IGF-Ⅰ were detected through Immunohistochemistry.The cell fraction of TGF-β1 and IGF-Ⅰ was recorded by image analytical system.Data were analyzed through PEMS3.1 statistical software.Results:(1)H-E stains:The chondrocytes in control group were regular,well-layer and homogeneous.While in experiment group,chondrocytes were swollen,irregular and coloboma at 4 weeks;chondrocytes were sparse,some assembled and swollen,a large amount of vacuolar lacuna were seen,and more coloboma in cartilagines at 8 weeks;(2)Immunohistochemistry:There was the expression of TGF-β1 in two groups,and The cell fraction in experiment group was more than in control group of the same period([WTBX]P[WTBZ]0.01).In experiment group,the cell fraction of defective locality of cartilagines was higher than that in intact locality of cartilagines at 4 weeks and 8 weeks([WTBX]P[WTBZ]0.01).The cell fraction in the experiment group(defective locality,intact locality of cartilagines)at 8 weeks was much higher than that of 4 weeks([WTBX]P[WTBZ]0.01).There was also the expression of IGF-Ⅰ in two groups.And the cell fraction in experiment group was more than that in control group of the same period([WTBX]P[WTBZ]0.01).The cell fraction of defective locality of cartilagines in experiment group at 4 weeks and 8 weeks was much more than that of intact locality([WTBX]P[WTBZ]0.01);The cell fraction at 8 weeks in experiment group(the defective locality,intact locality of cartilagines)was much more than that of 4 weeks([WTBX]P[WTBZ]0.01).Conclusion:The expression of TGF-β1 and IGF-Ⅰ of OA increased.The expression was increasing as the defection of the cartilagines got worse.The cartilage showed no repair.Further study is needed to investigate the mechanism." @default.
- W2384320370 created "2016-06-24" @default.
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- W2384320370 date "2007-01-01" @default.
- W2384320370 modified "2023-09-23" @default.
- W2384320370 title "Expression and significance of IGF-I,TGF-β in the chondrocyte of OA model in rabbit" @default.
- W2384320370 hasPublicationYear "2007" @default.
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