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- W2384328987 abstract "[Objective]To study the effect of angiotensin Ⅱ in different concentrations and different action time on MMPs in vascular smooth muscle cells and the influences of drugs on it.[Methods]The carotid artery of male SD rat was blooded,take the aorta thoracic,cell cultured conventionally 2 to 3 weeks,to passage after the celles grew into dense monolayer.15 healthy male SD rats were slelcted,3 days in captivity,gastric lavage accordint to 7.2g/kg,2 /d,7 d,in 2～3h after the last administration,femoral artery was blooded to separate the serum in aseptic condition,after inactivation of 56℃、30min,preservation-70℃.The cell culture medium was divided into control group、angiotensin II group、captopril group、losartan group and Xinkang group,to measure the changes of VSMC MMPs induced by angiotensin II in different concentrations and different action time.Results MMPs were induced and increased by angiotensin Ⅱ,especially in high concentrations.And MMP-9 was earlier than MMP-1 and MMP-2.The effect of angiotensin Ⅱ was significantly inhibited when cells were pretreated with the drugs.[Conclusions] MMPs may be induced and increased by angiotensin Ⅱ,especially in high concentrations.The drugs may have the inhibition effect against AngⅡ and MMPs induced in vascular smooth muscle cells." @default.
- W2384328987 created "2016-06-24" @default.
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- W2384328987 date "2012-01-01" @default.
- W2384328987 modified "2023-09-22" @default.
- W2384328987 title "Effect of Angiotensin II on MMPs in Vascular Smooth Muscle Cells and the Influences of Drugs on it" @default.
- W2384328987 hasPublicationYear "2012" @default.
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