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- W2384331445 abstract "【Objective】 To find the effect and mechanism of curcumin on the radiosensitivity of human breast cancer cells. 【Methods】 Breast cancer cell line in the logarithmic phase was divided into the control group, curcumin group, radiation group and combination group(radiation + curcumin). Apoptosis rate was ana- lyzed by flow cytometry(FCM). The radiosensitization effect was detected by clone experiment. The expressions of Akt and pAkt protein were detected by Western blotting. Results: Apoptosis rate in combination group was higher than radiation group 〔(28.49 ± 4.66) % vs(12.41 ± 4.98) %〕(q =20.07, P 0.01). Compared with radia- tion group, the values of Dq, Do and SF2 decreased significantly in combination group, and the SERDO was 1.293 by the clonogenic assay. The expression of Akt protein in each group was not significantly(F =3.467, P =0.051). The expression of pAkt protein was significantly higher than control group(q =4.71, P 0.05), while curcumin inhibited the expression of pAkt(q =4.11, P 0.05), and the expression of pAkt was significantly downer compare with radiation group(q =7.36, P 0.01). 【Conclusion】 Curcumin can enhance the radiosensi- tivity in breast cancer cell, that is about the down-regulation of the changer Akt to pAkt in the PI3K/Akt." @default.
- W2384331445 created "2016-06-24" @default.
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- W2384331445 date "2013-01-01" @default.
- W2384331445 modified "2023-09-26" @default.
- W2384331445 title "Effect of curcumin on radiosensitization of breast cancer cell MDA-MB-231" @default.
- W2384331445 hasPublicationYear "2013" @default.
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