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- W2384343025 abstract "Background: Gastritis and peptic ulcers are considered as major health problems worldwide with more than 80% of chronic active gastritis are due to the pathogenic bacterium H.pylori. Due to the emergence of antibiotic resistance among clinical strains of H. pylori, alternative approaches are increasingly needed. Methods: Methanolic extracts of Algerian originated Mentha rotundifolia, Eucalyptus globulus, Malva sylvestris, Inula viscosa, Achille aodorata and Utrica dioica and their contents of phenolics and flavonoids were evaluated for the in vitro antimicrobial activity against H. pylori , in addition to its associated urease inhibition. The minimum inhibitory concentrations (MICs) of these extracts was performed using control strain of H. pylori and standard agar diffusion method. Results: The highest phenolic and flavonoid contents were found in M.rotundifolia and E.globulus, while M.sylvestris showed the least phenolic contents. In addition, polyphenolic fractions exhibited antiH. pylori activity of all of the herbal extracts with highest activity for E.globulus (MIC 0.094mg/ml), I.viscosa, (0.375mg/ml) andU.dioica (0.75 mg/ml), low antimicrobial activity was revealed for A. odorata,M. rotundifolia and Malva sylvestris, respectively (MIC >1mg/ml). For the urease activity, all extracts showed inhibitory effect at concentration of 250mg/ml. However, the range of the urease inhibitory concentrations varied significantly among the extracts with highest activity and widest range found for E.globulus (70-90% at concentrations 8-125 mg/ml)." @default.
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- W2384343025 date "2013-01-01" @default.
- W2384343025 modified "2023-09-26" @default.
- W2384343025 title "In vitro susceptibility of Helicobacter pylori to urease inhibitory effects of polyphenolic extracts of local herbs from Algeria" @default.
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