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- W2384344226 abstract "Aim To observe the changes of matrix metallproteinases(MMPs) activities in mice with LPS induced acute lung injury and the intervention of soybean trypsin protease inhibitor.Methods 90 male rats were randomly divided into sham group(n=30),LPS group(n=30) and SBTI group(n=30).LPS group and SBTI group rats were injected with a single intratracheal dose of 0.3 ml LPS(6 mg·kg-1)saline,sham group rats were injected with the same dose of sham saline.SBTI group rats were given a single dose of SBTI(100 mg·kg-1·d-1) by intraperitoneal injection,the sham group and the LPS group were given the same dose of saline in the same way.10 rats were randomly killed on day 1,3and 7 following LPS or saline instillation.The activity of MMP-2 and MMP-9 in bronchoalveolar lavage fluids(BALF) and lung homogenate was studied by zymography;the expression of MMP-2 and MMP-9 in lung tissues was studied by immunohistochemistry.LPI was measured by mean of Bradford and pathological changes of lung tissue were observed.Results Compared with LPS group,the activity of MMP-2 and MMP-9 in BALF and lung homogenate of SBTI group decreased significantly,especially MMP-9 in day 7.The result of immunohistochemistry showed that acute lung injury caused by LPS was accompanied with increased expression of MMP-2 and MMP-9 in lung tissues.The expression of MMP-2 and MMP-9 decreased significantly in SBTI gruoup.Accordingly,lung penetrate index(LPI) was reduced and the histological changes in the lung tissues were alleviated significantly.Conclusions SBTI might take effect by means of inhibiting the expression and activity of matrix metalloproteinases in lung tissues and BALF,and sequentially,it attenuated basement membrane degradation and lung edema to protect lung from LPS induced acute lung injury." @default.
- W2384344226 created "2016-06-24" @default.
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- W2384344226 date "2008-01-01" @default.
- W2384344226 modified "2023-09-23" @default.
- W2384344226 title "Changes of matrix metalloproteinases activities in rats with LPS induced acute lung injury and the interventional effect of soybean trypsin protease inhibitor" @default.
- W2384344226 hasPublicationYear "2008" @default.
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