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- W2384344512 abstract "Objective To assess the diagnostic value of the single-photon-emission computed tomography (SPECT) and the magnetic resonance imaging (MRI) for Alzheimer's disease (AD) and vascular dementia (VD), and to explore the correlation between cerebral atrophy and cerebral regional blood flow and the degree of cognitive impairment in AD patients. Methods The temporal and frontal lobes and hippocampus were quantitatively detected by MRI and the cerebral regional blood flow in these regions was analysed semi-quantitatively by SPECT for 36 patients with AD, 32 with VD and 30 sex-matched non-demented elderly controls (NC). Results The hippocampal atrophy of AD and VD groups detected on MRI was significantly different from that of the NC group. Left hippocampal height was (9.27±3.43)mm in AD, (11.62±5.72)mm in VD and (12.13±2.97)mm in NC(P0.01). The examination of hypoperfusion by SPECT in VD and AD showed significant difference between AD and NC, VD and NC, respectively. RAR of the left temporal lobe for AD group was 0.60±0.07,for VD was 0.67±0.11 and for NC was 0.89±0.09(P0.01), respectively. In the early subclinical AD (MMSE 22-26), left hippocampal height of AD detected by MRI was (12.05±2.14)mm (P0.05, compared to that of NC), showing that hippocampal atrophy could not be detected by MRI. However, RAR of the left hippocampus by SPECT detection was 0.61±0.07 (P0.01, compared to that NC), showing hypoperfusion in the early subclinical AD. There were positve correlation between hippocampal hypoperfusion detected by SPECT and hippocampal atrophy by MRI and dementia examined by clinical scoring scale. Conclusions MRI is helpful for the diagnosis of AD. The degree of hippocampal hypoperfusion detected by SPECT and hippocampal atrophy detected by MRI were closely correlated with the severity of dementia determined by clinical scoring scales. In the very early stage of AD, local hippocampal hypoperfusion can be detected by SPECT, but hippocampal atrophy can not be detected by MRI. Various degrees of hippocampal hypoperfusion can be detected in all patients with AD by SPECT, suggesting that AD may correlate with hypoperfusion." @default.
- W2384344512 created "2016-06-24" @default.
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- W2384344512 date "2001-01-01" @default.
- W2384344512 modified "2023-09-28" @default.
- W2384344512 title "The diagnostic study on MRI and SPECT for the dementia" @default.
- W2384344512 hasPublicationYear "2001" @default.
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