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- W2384346535 abstract "Objective To investigate the therapeutic effect of carboxymethyl-β-1,3-glucan(CMG) on sepsis in mice. Methods The model mice with traumatic endotoxemia were used to determine the survival and histological effect of carboxymethyl-β-1,3-glucan (CMG) on the lungs. The effect of CMG on the expression of scanvenger receptor (SR) and the phagocytosis of alveolar macrophages (AM) was also investigated in vitro. Results CMG could improve the 48th hour survival rate of the mice with traumatic endotoxemia, mitigate their lung inflammatory injury of pulmonary tissues, inhibit the down-regulation of SR stimulated by LPS (P 0.05,P 0.01) and increase the AM phagocytosis of staphylococcus aureus which could be blocked by anti-SR monoclonal antibody, 2F8. Conclusions CMG can increase LPS clearance of AM induced by SR, strengthen hosts' nonspecific defensive function. So CMG may be an effective immunomodulator in treatment of sepsis." @default.
- W2384346535 created "2016-06-24" @default.
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- W2384346535 date "2003-01-01" @default.
- W2384346535 modified "2023-09-23" @default.
- W2384346535 title "Protective effect of carboxymethyl-β-1,3-glucan in treatment of sepsis in mice" @default.
- W2384346535 hasPublicationYear "2003" @default.
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