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- W2384357257 abstract "Objective To detect the expression and the function of 4-1BB ligand on tumor cell lines. Methods The expression level of 4-1BB ligand mRNA and protein on tumor cell lines was detected by quantitive RT-PCR and FACS. Using 4-1BBL monoclonal antibody(mAb) to stimulate the tumor cell lines, and the effect of proliferation of the tumor cell lines through 4-1BB LmAb was detected by MTT methods. Results The 4-1BB ligand mRNA was detected in Raji, THP-1, Jurkat and T1301, but only Raji and THP-1 could express 4-1BB ligand protein molecules accord-ingly(26.8% and 15.3% , respectively). 4-1BBLmAb could enhance the proliferation and survival in the tumor cell lines. Conclusions The expression levels of 4-1BB ligand on different tumor cell lines are different and may be related to their rapid growth. The 4-1BB ligand plays an important role in the proliferation and survival of tumor cell lines." @default.
- W2384357257 created "2016-06-24" @default.
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- W2384357257 date "2007-01-01" @default.
- W2384357257 modified "2023-09-23" @default.
- W2384357257 title "The Relationship between the Expression of 4-1BBL and the Proliferation of Tumor Cell Lines" @default.
- W2384357257 hasPublicationYear "2007" @default.
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