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- W2384357400 abstract "Objective:To investigate the changes of behavior and expression of hypothalamic gastrin-releasing peptide(GRP) mRNA after chronic and unpredictable mild stress(CUMS).Methods:Fourteen rats were randomly divided into control group(n=7) and depression group(n=7).The rats in the depression group were subjected to CUMS for 21 consecutive days.The behavior of 2 groups were observed.The expression of GRP mRNA was measured by real-time quantitative PCR.Results:The autonomic activity and sugar consumption in the depression group were significantly lower than those in the control(P0.001).The total distance,speed and rearing were significantly reduced in the stress group,revealed by the open field test(P0.001).The expression of GRP mRNA in the stress group was significantly higher than that in the control group(P0.05).Conclusion:The up-regulation of GRP mRNA probably plays a key in the behavior changes in rats exposed to stress." @default.
- W2384357400 created "2016-06-24" @default.
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- W2384357400 date "2012-01-01" @default.
- W2384357400 modified "2023-09-24" @default.
- W2384357400 title "Alterations of Behavior and Hypothalamic Gastrin-releasing Peptide mRNA Expression in Rats following Chronic Unpredictable Mild Stress" @default.
- W2384357400 hasPublicationYear "2012" @default.
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