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- W2384358639 abstract "Multiple sequences aligment analysis showed that the botulinum neurotoxin(BoNT) genes of the four different Clostridium botulinum type A strains share 92.2%～99.9% identical nucleotide sequences.To predict B cell epitopes,based on highly conserved BoNT/A amino acids sequence.And combined with the prediction of the flexibility and the turn or the coil regions of the secondary structure of BoNT/A,the results showed that the B cell epitopes of BoNT/A were probably located at or adjacent to its N-terminal No.440-450、465-480、538-549、699-710、751-760、1087-1095、1224-1231、1263-1270 of the heavy chain of BoNT/A,and N-terminal No.142-150 of the light chain.1263-1270 284-292 of the light chain.In a word,These datas obtained by the epitopes prediction using multiple parameters and the different analysis softwares are helpful for further epitope identification and design of multiepitopes-based vaccine of BoNT/A." @default.
- W2384358639 created "2016-06-24" @default.
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- W2384358639 date "2006-01-01" @default.
- W2384358639 modified "2023-09-25" @default.
- W2384358639 title "Analysis of genome sequence of Clostridium botulinum neurotoxin type A and its prediction of related B cell epitopes" @default.
- W2384358639 hasPublicationYear "2006" @default.
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