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- W2384361027 abstract "Objective To preliminarily discuss the effect and underlying mechanism of total glucosides of paeony( TGP) in treatment of patients with inactive ankylosing spondylitis( AS). Methods Thirtyeight AS patients were enrolled in this clinical trial. They were divided into NSAID,NSAID plus TGP and TGP groups. Fifteen healthy subjects were selected as normal controls. At baseline level and 24 weeks after treatment,BASDAI,VAS,BASFI and ASDAS scores were recorded,serum CRP,ESR,ALT,AST,BUN,CREAT were measured,the expression of peripheral TLR-4,TLR-5,TRAF6,Myd88 mRNA was detected by RTPCR and the serum TNF-α,IL-17α and TGF-β1were measured by liquid chip assay. Results The recurrence rate among three groups did not significantly differ( BASDAI≥4 as recurrence standard) during the course of treatment. Clinical assessment score and serum CRP,ESR,BUN,ALT,AST and CREAT did not significantly change after 24-week treatment( P 0. 05). Patients with AS had significantly higher baseline levels of TLR-4mRNA and TLR-5mRNA compared with healthy counterparts( P 0. 05). After 24-week treatment,patients receiving NSAID plus TGP had a significantly decreased level of TLR-4mRNA and TLR-5mRNA( P 0. 05).Patients in the TGP group had a declined level of TLR-5mRNA alone( P 0. 05). The serum levels of TNF-α,IL-17α and TGF-β1 in AS patients were significantly elevated compared with healthy subjects after 24-week therapy( all P 0. 05). In all groups,the expression of TNF-α and IL-17α was significantly down-regulated following 24-week treatment( P 0. 05). Conclusions TGP is of potential for treating inactive AS,and the underlying mechanism of down-regulating relevant inflammatory factors and blocking TLR-4 /5 signal pathway may be employed." @default.
- W2384361027 created "2016-06-24" @default.
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- W2384361027 date "2014-01-01" @default.
- W2384361027 modified "2023-09-24" @default.
- W2384361027 title "Study of mechanism of glucosides of paeony in treating inactive ankylosing spondylitis patients" @default.
- W2384361027 hasPublicationYear "2014" @default.
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