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- W2384366128 abstract "Hypercholesterolemia is a major risk factor for atherosclerosis and heart disease. Current cholesterol2limiting therapies fail in some patients , where additional therapeutic targets are needed. PCSK9 encodes a pro2protein convertase subtilisinP kexin type 9a that plays an important role in cholesterol metabolism by the modulation of LDL receptor levels in the liver. Gain2of2function mutations of PCSK9 resulted in elevated levels of LDL2cholesterol in the plasma. Loss2of2function mutations led to high levels of the LDL receptor and low LDL2cholesterol . This review focuses on the structure , functions and pharmacological targets of PCSK9." @default.
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- W2384366128 date "2009-01-01" @default.
- W2384366128 modified "2023-09-25" @default.
- W2384366128 title "Selecting Pharmacological Targets of PCSK9" @default.
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