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- W2384367170 abstract "Purpose:The goal of this study is to observe the inhibition effect on proliferation and the changes of protein expression of C myc,p16 gene on glioma cell line C6 treated by Dimethylformamide (DMF).Methods:The [ 3H] TdR assay was used to evaluate the effect of DMF on cell proliferation, C myc and p16 expression were studied by immunohistochemical technique. Results:The numbers of CPM decreased by DMF, suggesting the amount of cells DNA decreased. The protein expression of C myc gene was notably decreased, while p16 gene was notably increased by DMF. Conclusions:DMF caused a dose dependent proliferation inhibitory effect, one of the mechanisms of the effect should be that DMF decreased C myc expression and increased p16 gene activity." @default.
- W2384367170 created "2016-06-24" @default.
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- W2384367170 date "2000-01-01" @default.
- W2384367170 modified "2023-09-25" @default.
- W2384367170 title "The effect of differentiation inducing activity of dimethylformamide and gene expression in glioma cell line C6" @default.
- W2384367170 hasPublicationYear "2000" @default.
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