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- W2384378512 abstract "Objectives To investigate the expression of matrix metalloproteinases-9(MMP-9) and its tissue inhibitor of meta11oproteinases-1(TIMP-1) in plasma of patients with colorectal carcinoma, in order to reveal its relationship with the invasion, metastasis and prognosis of the tumor.Methods Plasma concentrations of MMP-9 and TIMP-1 were measured by ELISA assay in 50 patients with colorectal carcinoma pre-and postoperatively;their relationship with clinicopathologic manifestations was analyzed.Results The concentration levels of MMP-9 and TIMP-1 in the patients with poorly differentiated tumors and those in TNM Ⅲ or Ⅳ stages were significantly higher than in cases with well differentiated tumors and those in TNM Ⅰ or Ⅱ stages(P0.01).The concentration levels decreased obviously after operation(PMMP-90.01, PTIMP-10.05), while there were no significant changes after chemotherapy.Conclusions The expression levels of MMP-9 and TIMP-1 were both significantly correlated with the degree of malignancy and biological behavior of the carcinoma.Higher levels of MMP-9 means worse prognosis in patients with carcinoma.Detecting the expression of MMP-9 and TIMP-1 may be useful in predicting the biological behavior and prognosis of colorectal carcinoma." @default.
- W2384378512 created "2016-06-24" @default.
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- W2384378512 date "2009-01-01" @default.
- W2384378512 modified "2023-09-26" @default.
- W2384378512 title "Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in plasma of patients with colorectal carcinoma" @default.
- W2384378512 hasPublicationYear "2009" @default.
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