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- W2384379670 abstract "Objective The aim of this study is to determine the docking effects of the heteromultimeric combination of Cx43 and Cx45 and the phosphorylation on the permeability properties of their channels.Methods The Hela cells were transfected DNA encoding Cx43 or Cx45 colocalized to form bi-heteromeric and mono-heteromeric channels.The dye permeability of various combinations of Cx43 and Cx45 under epifluorescent illumination before and after 200 nmol/L 12-0-tetradecanoylphorbol-13-acetae(TPA)treatment was determined by microinjection with rhodamine123.Results Homotypic Cx43(HoCx 43)channels were the best coupled in the different combination of connexins.The permeability of mono-heteromeric Cx45-Cx43/45 channels(MH45)injected from the side of Cx45 is the least compared with the channels of MH45 injected from the side of Cx43/45,bi-heteromeric Cx43/45(BH43/45) and homotypic Cx45(HoCx45).We normalized the changes in coupling ratio for heteromultimeric channels according to the change in HoCx43 or HoCx45 channels.The coupling ratios for both channels of BH43/45 and mono-heteromeric Cx43-Cx43/45(MH43) were decreased compared with HoCx43 channels.For MH45 channel,the coupling ratios of channels injected from in the side of cells expressing Cx43/Cx45 were larger than those from the side of cells expressing Cx45.After TPA treatment,the coupling ratio of HoCx43 was reduced and this reduction in coupling was accentuated for channels with bi-heteromeric or mono-heteromeric connexons.Conclusion Co-expressed Cx43 and Cx45 can form bi-heteromenic and mono-heteromeric channels,which result in low gap junctional communication and insensitivity to phosphorylation.The permeability of mono-heteromeric channels depending on the direction of dye injection might relate the anatomical basic for the reentry in arrhythmia." @default.
- W2384379670 created "2016-06-24" @default.
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- W2384379670 date "2003-01-01" @default.
- W2384379670 modified "2023-09-25" @default.
- W2384379670 title "Modulation of cardiac gap junction by heteromeric junction channels and phosphorylation" @default.
- W2384379670 hasPublicationYear "2003" @default.
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