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- W2384383579 abstract "Objective To investigate the relationship between the peak bone mineral density and estrogen receptor allelic variants in Chinese Han young women. Methods From March 2000 to July 2001, one hundred and fifty-nine young healthy women (25-37 year-old) were voluntarily enrolled in the study. ① BMD was measured using DXEA (Hologic QDR-4500) at lumbar and hip.② The polymorphisms of ER gene were detected by PCR-RFLPs (restriction fragment length polymorphisms). ③ The relationship between BMD and the polymorphisms of ER gene, as well as some other characteristics, were analyzed. Results ① Lumbar BMD was positively related to height, weight and body mass index (BMI), whereas, the femoral neck BMD only to weight, and the BMD of other sites of hip to BMI. ② In Ward's triangle,BMD of the subjects with PP genotype was significantly lower than those with Pp and pp genotypes. ③ There was no significant difference among three XbaI polymorphism groups. ④ BMD of the subjects with PPxx genotype was higher than those of other genotypes, and the lowest BMD was in the subjects with PPXx genotype.The subjects with PPxx genotype presented significantly higher BMD than those with PPXx and PpXX genotypes at femoral Neck, and also higher than those with PPXx , PpXX , PpXx , ppXx and ppxx genotypes at Inter site. But at ward's triangle, BMD of the subjects with Ppxx and ppXx was significantly higher than those with PPXx and PPXX . Conclusions ① Body weight and BMI play important roles in PBMD of Chinese Han women. ② Our data suggest that genetic variation at the ER gene may affect the attainment and maintenance of peak bone mass in young women." @default.
- W2384383579 created "2016-06-24" @default.
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- W2384383579 date "2004-01-01" @default.
- W2384383579 modified "2023-09-27" @default.
- W2384383579 title "The relationship between estrogen receptor allelic variants and peak bone mineral density in Beijing women" @default.
- W2384383579 hasPublicationYear "2004" @default.
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