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- W2384384199 abstract "Objective To determine whether cutaneous TLR 2 and 4 expression vary with dermatitis types. Methods Dermatitis models were established by topical application of either tumor promotion agent (phorbol ester),oxazolone,or repeated tape-stripping. Cutaneous expression of TLR 2 and 4 was assessed by immunohistochemistry methods. Results Cutaneous inflammation up-regulated epidermal TLR 2 and dermal TLR 4 expression regardless of the methods inducing inflammation. A greater increase in TLR expression was observed in dermatitis induced by either phorbol ester or oxazolone,which exhibited more inflammatory cell infiltration. In contrast,a minor increase in TLR expression was seen in dermatitis model induced by tape-stripping,which showed less inflammatory cell infiltration. Conclusion Cutaneous inflammation differentially up-regulates TLR 2 and 4 expressions in epidermis and dermis. And the extent of increased TLR2 expression is determined by the severity of inflammation" @default.
- W2384384199 created "2016-06-24" @default.
- W2384384199 creator A5023866633 @default.
- W2384384199 date "2009-01-01" @default.
- W2384384199 modified "2023-09-25" @default.
- W2384384199 title "Cutaneous Expression of Toll-like Receptor2 and 4 in Various Dermatitis Models" @default.
- W2384384199 hasPublicationYear "2009" @default.
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