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- W2384389235 abstract "Objective:To investigate the effects of Baogan granula on fibrosis level of experimental liver fibrosis in rats.Methodes: 60 male Wister rats were separated into six groups:control,model,Baogan granula high,median,low dose groups and malotilate group.All rats except those in the control group were given subcutaneous injection of 40% carbon tetrachloride(once every 3 days for 11 weeks).3 weeks later,rats in the treatment group were also given Baogan granula at 18,9.0,4.5g/(kg·d) daily for 8 weeks via gastrogavage.At the end of the treatment,the levels of hyaluronic acid(HA),laminin(LN),precollagen ⅡI(PCⅡI) in serum and HYP in liver tissue were detected,the pathohistological changes were observed under light microscope.Results: Compared with model group,Baogan granula could protect hepatic function,especially the middle and high doses,could significantly degrade the serum levels of HA,LN,PCⅡI and the exorbitant HYP in liver tissue;Histopathologic examination also showed its significant amelioration effect on experimental liver fibrosis.Conclusion: Baogan granula Can greatly protect from liver fibrosis in rats induced by CCl4." @default.
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- W2384389235 date "2008-01-01" @default.
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- W2384389235 title "Experimental Studies of Baogan Granula on Anti-hepatic Fibrosis in Rats" @default.
- W2384389235 hasPublicationYear "2008" @default.
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