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- W2384389546 abstract "Objective To stuey the accumulated amount of lidocaine hydrocholoride transport through isolated rats skin depending on different time by each formula of oleic acid+tween20+propylene glycol (OA+Tween20+PGL) as penetration enhancers system. Methods To adopt factorial analysis design; (OA+Tween20) and PGL as 2 factors 3 levels respectively,establishing the list of factorial analysis; Using Franz cell as experimental diffusion instrument; abdominal skins of SD rats as transdermal barrier. At different time to draw the liquid from the receptor to test the concentration of lidocaine hydrocholoride. Using the technique of 3D diagram of solubilization to determine the optimal ratio between oleic acid and tween20; the orthogonal range analysis had also been performed to describe the effects on the penetration of lidocaine hydrocholoride between OA and PGL. Results The ratio of OA to tween20 was 1∶9;The optiomal formulas were 5%(PG)+5%(OA)与15%(PG)+3%(OA) which possess 393.190(μg/cm2h)and 357.588(μg/cm2h)respectively. Each Q-t has good nature of linear regression; each level of PGL and OA exists remarkable difference(P=0.000~0.022). Propylene glycol and oleic acid exists marked interaction in permeation of lidocaine hydrocholoride (P0.001);OA had more marked effects on the penetration of lidocaine hydrocholoride.than PGL. Conclusion Between PGL and OA exists marked interaction to promoting permeation of lidocaine hydrocholoride and proving that PGL works well in coordination with OA at reseanable formulas." @default.
- W2384389546 created "2016-06-24" @default.
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- W2384389546 date "2008-01-01" @default.
- W2384389546 modified "2023-09-25" @default.
- W2384389546 title "The Effects of Lidocaine Hydrocholoride Emulsion Transdermal Penetration by the Oleic Acid-tween20,Propylene Glycol System" @default.
- W2384389546 hasPublicationYear "2008" @default.
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