Matches in SemOpenAlex for { <https://semopenalex.org/work/W2384390103> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2384390103 abstract "Aim: To explore the effects of marrow mesenchymal stem cells(MSCs) on the clinical manifestation and the immune function of EAMG. Methods: 20 EAMG rats were determined and divided randomly into the transplantation group and the model control group,each group had 10 rats, and prepared 10 healthy rats as the normal control group. MSCs were obtained from Lewis rats and planted in plastic culture capsule,then cultured and expanded in vitro. MSCs were identified by flow cytometry. Transplantation group were injected with 1×106 MSCs diluted in PBS (100 μL) and with an equal volume of PBS in the model control and the normal control group. And then the body weight and clinical symptoms of rats in transplantation and model control group were evaluated at the same time every day. The titers of AChRa97-116-Ab in plasmawere detected by ELISA after 2 weeks of transplantation. The expression of T-bet/GATA-3 in PBMCs were measured by RT-PCR in the three groups, IFN-γ, IL-4 in plasma were detected by ELISA in the three groups after 3 weeks of transplantation. Results: The clinical score, the titers of AChRa97-116-Ab, and the expression of T-bet/GATA-3, IFN-γ, IL-4 in the transplantation group were obviously lower than those in the model control group. There were no significant difference between the transplantation and the normal control group. IFN-γ and IL-4 were positively correlated with T-bet and GATA-3 in the model control group, respectively. Conclusion: Bone marrow mesenchymal stem cells could ameliorate muscular weakness in EAMG rats via suppressing T-bet/GATA-3 expression and downregulating of AChR-specific B-cell responses and AChR- reactive T-cell function." @default.
- W2384390103 created "2016-06-24" @default.
- W2384390103 creator A5047170949 @default.
- W2384390103 date "2009-01-01" @default.
- W2384390103 modified "2023-09-23" @default.
- W2384390103 title "Effects of Bone Marrow Mesenchymal Stem Cells on the Clinical Manifestation and the Immune Function of Experimental Autoimmune Myasthenia Gravis" @default.
- W2384390103 hasPublicationYear "2009" @default.
- W2384390103 type Work @default.
- W2384390103 sameAs 2384390103 @default.
- W2384390103 citedByCount "0" @default.
- W2384390103 crossrefType "journal-article" @default.
- W2384390103 hasAuthorship W2384390103A5047170949 @default.
- W2384390103 hasConcept C126322002 @default.
- W2384390103 hasConcept C134018914 @default.
- W2384390103 hasConcept C137061746 @default.
- W2384390103 hasConcept C142724271 @default.
- W2384390103 hasConcept C16685009 @default.
- W2384390103 hasConcept C198826908 @default.
- W2384390103 hasConcept C202751555 @default.
- W2384390103 hasConcept C203014093 @default.
- W2384390103 hasConcept C2778105408 @default.
- W2384390103 hasConcept C2780007613 @default.
- W2384390103 hasConcept C2911091166 @default.
- W2384390103 hasConcept C553184892 @default.
- W2384390103 hasConcept C55493867 @default.
- W2384390103 hasConcept C71924100 @default.
- W2384390103 hasConcept C86803240 @default.
- W2384390103 hasConcept C8891405 @default.
- W2384390103 hasConceptScore W2384390103C126322002 @default.
- W2384390103 hasConceptScore W2384390103C134018914 @default.
- W2384390103 hasConceptScore W2384390103C137061746 @default.
- W2384390103 hasConceptScore W2384390103C142724271 @default.
- W2384390103 hasConceptScore W2384390103C16685009 @default.
- W2384390103 hasConceptScore W2384390103C198826908 @default.
- W2384390103 hasConceptScore W2384390103C202751555 @default.
- W2384390103 hasConceptScore W2384390103C203014093 @default.
- W2384390103 hasConceptScore W2384390103C2778105408 @default.
- W2384390103 hasConceptScore W2384390103C2780007613 @default.
- W2384390103 hasConceptScore W2384390103C2911091166 @default.
- W2384390103 hasConceptScore W2384390103C553184892 @default.
- W2384390103 hasConceptScore W2384390103C55493867 @default.
- W2384390103 hasConceptScore W2384390103C71924100 @default.
- W2384390103 hasConceptScore W2384390103C86803240 @default.
- W2384390103 hasConceptScore W2384390103C8891405 @default.
- W2384390103 hasOpenAccess W2384390103 @default.
- W2384390103 hasRelatedWork W1624400649 @default.
- W2384390103 hasRelatedWork W2272762185 @default.
- W2384390103 hasRelatedWork W2355361295 @default.
- W2384390103 hasRelatedWork W2358569186 @default.
- W2384390103 hasRelatedWork W2359407680 @default.
- W2384390103 hasRelatedWork W2360985027 @default.
- W2384390103 hasRelatedWork W2361878547 @default.
- W2384390103 hasRelatedWork W2363161098 @default.
- W2384390103 hasRelatedWork W2370099235 @default.
- W2384390103 hasRelatedWork W2373322829 @default.
- W2384390103 hasRelatedWork W2384028450 @default.
- W2384390103 hasRelatedWork W2386088849 @default.
- W2384390103 hasRelatedWork W2386172420 @default.
- W2384390103 hasRelatedWork W2391087082 @default.
- W2384390103 hasRelatedWork W2423146422 @default.
- W2384390103 hasRelatedWork W2566201330 @default.
- W2384390103 hasRelatedWork W3029914012 @default.
- W2384390103 hasRelatedWork W3030619553 @default.
- W2384390103 hasRelatedWork W3031461452 @default.
- W2384390103 hasRelatedWork W336251672 @default.
- W2384390103 isParatext "false" @default.
- W2384390103 isRetracted "false" @default.
- W2384390103 magId "2384390103" @default.
- W2384390103 workType "article" @default.