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- W2384394770 abstract "OBJECTIVE The purpose is to optimize the preparation of lung targeting microspheres of streptomycin sulfate using the biodegradable materials-gelatin.METHODS The gelatin microspheres of streptomycin sulfate (SMS-GMS) were prepared with the emulsifying method and some factors effecting the technology were analyzed with the orthogonal test design. The surface morphology of the microspheres was observed by SEM. The formation of the drug microspheres was confirmed by FTIR. The mean diameter and the size distribution of microspheres,the drug-loading rate,the entrapment rate and stability were examined.RESULTS The SMS-GMS were regular in their morphology,drug was enveloped in microspheres. The data showed that the mean diameter of SMS-GMS was 12.269 μm,with 91.5% of the microspheres ranging from 5.0 μm to 25.0 μm. The drug-loading rate and the entrapment rate were 42.6% and 53.8%. The repeatability of the technology was good. The content,shape and size of the microspheres showed no remarkable change after storage at 37 ℃、RH 75 % for 3 months.CONCLUSION The technology of preparation was successful and the SMS-GMS can be used for study of lung target." @default.
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- W2384394770 date "2005-01-01" @default.
- W2384394770 modified "2023-09-24" @default.
- W2384394770 title "The preparation of streptomycin sulfate gelatin microspheres for lung targeting" @default.
- W2384394770 hasPublicationYear "2005" @default.
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