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- W2384394842 abstract "The mouse SIGIRR gene recombinant adenovirus was constructed and identified as the basic research of SIGIRR in the prevention and treatment of acute lung injury(ALI).AdEasyTM system was used to construct the mouse SIGIRR gene recombinant adenovirus,and detect the SIGIRR mRNA and SIGIRR protein expression in infected cells and tissues.A high-titer adenovirus was prepared by repeated amplification.The result showed that mouse SIGIRR gene recombinant adenovirus(Ad-mSIGIRR)was successfully constructed and the titer is 5×1010 pfu/mL which matched the requirement of next experiment.After intratracheal instillation of mouse SIGIRR gene recombinant adenovirus,SIGIRR protein over-expression was found in mouse lung tissue by Western blot and immunohistochemistry,and did not cause pathological lesions in normal mouse lung tissues with the experimental dose.This study confirmed that mouse SIGIRR gene recombinant adenovirus could enhance the expression of SIGIRR in mice after intratracheal instillation,and did not cause pathological lesions in normal mouse lung tissues with the experimental dose 5×1010 puf/mL." @default.
- W2384394842 created "2016-06-24" @default.
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- W2384394842 date "2013-01-01" @default.
- W2384394842 modified "2023-09-26" @default.
- W2384394842 title "Construction and Identification of Mouse SIGIRR Gene Recombinant Adenovirus" @default.
- W2384394842 hasPublicationYear "2013" @default.
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