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- W2384394904 abstract "Objective To investigate the repair effect of chitooligosaccharide(COS)on the crushed sciatic nerve of mouse.Methods Fifty ICR mice,half female and male,were randomly divided into five groups:the high dose COS group,medium dose COS group,low dose COS group,mecobalamine(positive control)group and normal saline(blank control)group.These mice after sciatic nerve crushing were received COS,mecobalamine or normal saline by intraperitoneal injection every day.The effect of COS on the crushed sciatic nerve was observed by sciatic function index(SFI),histomorphology and electron microscope.Results Comparing with the blank control group,SFI scores of COS groups were significantly higher(P0.01).The transverse section area of gastrocnemius muscles in COS groups were larger than that in the blank control group.The number of regeneration nerve fibers,thick and maturity degree of regeneration myelinated nerve sheath in COS groups were greater than those in the blank control group(P0.01).Conclusion COS can promote the regeneration of peripheral nerve and improve the recovery of its functions." @default.
- W2384394904 created "2016-06-24" @default.
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- W2384394904 date "2010-01-01" @default.
- W2384394904 modified "2023-09-27" @default.
- W2384394904 title "Experimental Study of the Repair Effect of Chitooligosaccharide on the Crushed Sciatic Nerve of Mouse" @default.
- W2384394904 hasPublicationYear "2010" @default.
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